Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50255245
Substrate
n/a
Meas. Tech.
ChEMBL_516273 (CHEMBL985943)
IC50
3990±n/a nM
Citation
 Tao, YH; Xu, HB; Yang, XL Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett 19:731-4 (2009) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
Abat | GABT_RAT | Gabat | Gamma-amino-N-butyrate transaminase
Type:
PROTEIN
Mol. Mass.:
56465.74
Organism:
Rattus norvegicus
Description:
ChEMBL_884621
Residue:
500
Sequence:
MAFLLTTRRLVCSSQKNLHLFTPGSRYISQAAAKVDFEFDYDGPLMKTEVPGPRSQELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLRESLMSVAPKGMCQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVTDNQQEEARCLEEVEDLIVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMSFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVAHAGKTLLTGLLDLQAQYPQFVSRVRGRGTFCSFDTPDEAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSGILADFK
  
Inhibitor
Name:
BDBM50255245
Synonyms:
3-chloro-1-(4-hydroxyphenyl)propan-1-one | CHEMBL500579
Type:
Small organic molecule
Emp. Form.:
C9H9ClO2
Mol. Mass.:
184.62
SMILES:
Oc1ccc(cc1)C(=O)CCCl
Structure:
Search PDB for entries with ligand similarity: