Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50277039
Substrate
n/a
Meas. Tech.
ChEMBL_541031 (CHEMBL1024731)
Ki
583.7±n/a nM
Citation
 Sikazwe, DM; Nkansah, NT; Altundas, R; Zhu, XY; Roth, BL; Setola, V; Ablordeppey, SY Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups. Bioorg Med Chem 17:1716-23 (2009) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50277039
Synonyms:
9-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-3-(4-chlorophenyl)-3,9-diazabicyclo[4.2.1]nonane | CHEMBL458342
Type:
Small organic molecule
Emp. Form.:
C21H23ClN4
Mol. Mass.:
366.887
SMILES:
Clc1ccc(cc1)N1CCC2CCC(C1)N2Cc1c[nH]c2ncccc12
Structure:
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