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Target
Potassium voltage-gated channel subfamily H member 2
Ligand
BDBM50279717
Substrate
n/a
Meas. Tech.
ChEMBL_545264 (CHEMBL1020710)
IC50
4700±n/a nM
Citation
 Du, L; Li, M; Yang, Q; Tang, Y; You, Q; Xia, L Molecular hybridization, synthesis, and biological evaluation of novel chroman I(Kr) and I(Ks) dual blockers. Bioorg Med Chem Lett 19:1477-80 (2009) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily H member 2
Synonyms:
ERG | KCNH2 | KCNH2_CAVPO
Type:
PROTEIN
Mol. Mass.:
18377.97
Organism:
Cavia porcellus
Description:
ChEMBL_545264
Residue:
162
Sequence:
AVWDWLILLLVIYTAVFTPYSAAFLLKEPEEDAQTADCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY
  
Inhibitor
Name:
BDBM50279717
Synonyms:
1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(4-(4-methylpiperazin-1-yl)butyl)imidazolidine-2,4-dione | CHEMBL473496
Type:
Small organic molecule
Emp. Form.:
C21H28ClN5O3
Mol. Mass.:
433.932
SMILES:
CN1CCN(CCCCn2c(O)cn(N=C3CCOc4ccc(Cl)cc34)c2=O)CC1 |w:14.13|
Structure:
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