Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 1
Ligand
BDBM50248591
Substrate
n/a
Meas. Tech.
ChEMBL_566227 (CHEMBL963308)
Ki
16±n/a nM
Citation
 Biju, P; Taveras, AG; Yu, Y; Zheng, J; Hipkin, RW; Fossetta, J; Fan, X; Fine, J; Lundell, D 3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists. Bioorg Med Chem Lett 19:1434-7 (2009) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50248591
Synonyms:
(R)-3-(4-(cyclopropyl(phenyl)methylamino)-1,2,5-thiadiazol-3-ylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL462024
Type:
Small organic molecule
Emp. Form.:
C21H23N5O2S
Mol. Mass.:
409.505
SMILES:
CN(C)C(=O)c1cccc(Nc2nsnc2N[C@H](C2CC2)c2ccccc2)c1O |r|
Structure:
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