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Target
Protection of telomeres protein 1
Ligand
BDBM50276827
Substrate
n/a
Meas. Tech.
ChEMBL_541324 (CHEMBL1027378)
IC50
17000±n/a nM
Citation
 Fu, YT; Keppler, BR; Soares, J; Jarstfer, MB BRACO19 analog dimers with improved inhibition of telomerase and hPot 1. Bioorg Med Chem 17:2030-7 (2009) [PubMed]  Article 
Target
Name:
Protection of telomeres protein 1
Synonyms:
POT1 | POTE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71443.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_541324
Residue:
634
Sequence:
MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSSKYFNFTTEDHKMVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTANQHSDVICQSEPDDSFPSSGSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQYRIRAKLRSYKPRRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKNQKGRKVAVHFVKNNGILPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGHEDLELLDLSAPFLIQGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQYVFVMTFTLDDGTGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAYPWLECFIKSYNVTNGTDNQICYQIFDTTVAEDVI
  
Inhibitor
Name:
BDBM50276827
Synonyms:
CHEMBL448813 | N,N',N'',N'''-(9,9'-(hexane-1,6-diylbis(azanediyl))bis(acridine-9,6,3-triyl))tetrakis(3-(pyrrolidin-1-yl)propanamide)
Type:
Small organic molecule
Emp. Form.:
C60H78N12O4
Mol. Mass.:
1031.3393
SMILES:
O=C(CCN1CCCC1)Nc1ccc2c(NCCCCCCNc3c4ccc(NC(=O)CCN5CCCC5)cc4nc4cc(NC(=O)CCN5CCCC5)ccc34)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Structure:
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