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Target
Alpha-2B adrenergic receptor
Ligand
BDBM50250521
Substrate
n/a
Meas. Tech.
ChEMBL_564353 (CHEMBL957655)
EC50
4200±n/a nM
Citation
 Davis, RA; Fechner, GA; Sykes, M; Garavelas, A; Pass, DM; Carroll, AR; Addepalli, R; Avery, VM; Hooper, JN; Quinn, RJ (-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata. Bioorg Med Chem 17:2497-500 (2009) [PubMed]  Article 
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Type:
Enzyme
Mol. Mass.:
49964.20
Organism:
Homo sapiens (Human)
Description:
P18089
Residue:
450
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
  
Inhibitor
Name:
BDBM50250521
Synonyms:
(-)-dibromophakellin | CHEMBL447696 | dibromophakellin
Type:
Small organic molecule
Emp. Form.:
C11H11Br2N5O
Mol. Mass.:
389.046
SMILES:
NC1=N[C@H]2n3c(Br)c(Br)cc3C(=O)N3CCC[C@]23N1 |r,t:1|
Structure:
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