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Target
Tyrosine-protein kinase ITK/TSK
Ligand
BDBM50257915
Substrate
n/a
Meas. Tech.
ChEMBL_562396 (CHEMBL1018829)
IC50
11±n/a nM
Citation
 Riether, D; Zindell, R; Kowalski, JA; Cook, BN; Bentzien, J; Lombaert, SD; Thomson, D; Kugler, SZ; Skow, D; Martin, LS; Raymond, EL; Khine, HH; O'Shea, K; Woska, JR; Jeanfavre, D; Sellati, R; Ralph, KL; Ahlberg, J; Labissiere, G; Kashem, MA; Pullen, SS; Takahashi, H 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett 19:1588-91 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ITK/TSK
Synonyms:
EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:
Protein
Mol. Mass.:
71839.20
Organism:
Homo sapiens (Human)
Description:
Q08881
Residue:
620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
  
Inhibitor
Name:
BDBM50257915
Synonyms:
CHEMBL493007 | N-(1-(2-hydroxy-2-methylpropyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H30N6O2S
Mol. Mass.:
478.61
SMILES:
CC(C)(O)Cn1c(NC(=O)c2ccc(s2)-c2cn[nH]c2)nc2cc(CN3CCCCC3)ccc12
Structure:
Search PDB for entries with ligand similarity: