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Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50107296
Substrate
n/a
Meas. Tech.
ChEMBL_564380 (CHEMBL962375)
IC50
1300±n/a nM
Citation
 Geyer, JA; Keenan, SM; Woodard, CL; Thompson, PA; Gerena, L; Nichols, DA; Gutteridge, CE; Waters, NC Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett 19:1982-5 (2009) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50107296
Synonyms:
(E)-1-(2,4-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one | 1-(2,4-Dimethoxy-phenyl)-3-naphthalen-1-yl-propenone | 1-(2,4-dimethoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one | CHEMBL139856 | WR-289016
Type:
Small organic molecule
Emp. Form.:
C21H18O3
Mol. Mass.:
318.3658
SMILES:
COc1ccc(C(=O)\C=C\c2cccc3ccccc23)c(OC)c1
Structure:
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