Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50257133
Substrate
n/a
Meas. Tech.
ChEMBL_562513 (CHEMBL1014505)
IC50
500±n/a nM
Citation
 Manku, S; Allan, M; Nguyen, N; Ajamian, A; Rodrigue, J; Therrien, E; Wang, J; Guo, T; Rahil, J; Petschner, AJ; Nicolescu, A; Lefebvre, S; Li, Z; Fournel, M; Besterman, JM; Déziel, R; Wahhab, A Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors. Bioorg Med Chem Lett 19:1866-70 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50257133
Synonyms:
(S)-benzyl 1-(2-(4-methoxyphenyl)thiazol-4-yl)-5-(sulfamoylamino)pentylcarbamate | CHEMBL523033
Type:
Small organic molecule
Emp. Form.:
C23H28N4O5S2
Mol. Mass.:
504.622
SMILES:
COc1ccc(cc1)-c1nc(cs1)[C@H](CCCCNS(N)(=O)=O)NC(=O)OCc1ccccc1 |r|
Structure:
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