Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50249165
Substrate
n/a
Meas. Tech.
ChEMBL_499722 (CHEMBL968695)
IC50
0.5±n/a nM
Citation
 Zhang, P; Huang, W; Wang, L; Bao, L; Jia, ZJ; Bauer, SM; Goldman, EA; Probst, GD; Song, Y; Su, T; Fan, J; Wu, Y; Li, W; Woolfrey, J; Sinha, U; Wong, PW; Edwards, ST; Arfsten, AE; Clizbe, LA; Kanter, J; Pandey, A; Park, G; Hutchaleelaha, A; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett 19:2179-85 (2009) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50249165
Synonyms:
CHEMBL515254 | N-(4-chloro-2-(5-chloropyridin-2-ylcarbamoyl)phenyl)-4-(N,N-dimethylcarbamimidoyl)-2-((2-methoxyethyl)(methyl)amino)benzamide
Type:
Small organic molecule
Emp. Form.:
C26H28Cl2N6O3
Mol. Mass.:
543.445
SMILES:
COCCN(C)c1cc(ccc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1)C(=N)N(C)C
Structure:
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