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TargetVitamin D3 receptor
LigandBDBM50293274
Substrate/Competitorn/a
Meas. Tech.ChEMBL_562893
EC50 0.69±n/a nM
Citation Laverny, GPenna, GUskokovic, MMarczak, SMaehr, HJankowski, PCeailles, CVouros, PSmith, BRobinson, MReddy, GSAdorini, L Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3. J Med Chem52:2204-13 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vitamin D3 receptor
Name:Retinoic acid receptor RXR-alpha/Vitamin D3 receptor
Synonyms:1,25-dihydroxyvitamin D3 receptor | Nuclear receptor subfamily 1 group I member 1 | VDR
Type:Protein
Mol. Mass.:48288.72
Organism:Homo sapiens (Human)
Description:P11473
Residue:427
Sequence:
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50293274
NameBDBM50293274
Synonyms:1alpha,25(OH)2-24-oxo-16-ene-20-cyclopropyl-vitamin D3 | CHEMBL492749
TypeSmall organic molecule
Emp. Form.C28H40O4
Mol. Mass.440.6148
SMILESCC(C)(O)C(=O)CCC1(CC1)C1=CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r,t:12|
Structure
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n/a