Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50267510
Substrate
n/a
Meas. Tech.
ChEMBL_563499 (CHEMBL961047)
Ki
1156±n/a nM
Citation
 Herth, MM; Kramer, V; Piel, M; Palner, M; Riss, PJ; Knudsen, GM; Rösch, F Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorg Med Chem 17:2989-3002 (2009) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50267510
Synonyms:
(3-(2-Fluoroethoxy)-2-methoxyphenyl)-(1-(2-p-toluylphenylethyl)-piperidine-4-yl)-methanol | CHEMBL476839
Type:
Small organic molecule
Emp. Form.:
C24H32FNO3
Mol. Mass.:
401.5142
SMILES:
COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1
Structure:
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