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Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Ligand
BDBM50259105
Substrate
n/a
Meas. Tech.
ChEMBL_500708 (CHEMBL966924)
IC50
>10000±n/a nM
Citation
 Deninno, MP; Andrews, M; Bell, AS; Chen, Y; Eller-Zarbo, C; Eshelby, N; Etienne, JB; Moore, DE; Palmer, MJ; Visser, MS; Yu, LJ; Zavadoski, WJ; Michael Gibbs, E The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents. Bioorg Med Chem Lett 19:2537-41 (2009) [PubMed]  Article 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Synonyms:
61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1
Type:
Protein
Mol. Mass.:
61245.69
Organism:
Homo sapiens (Human)
Description:
P54750
Residue:
535
Sequence:
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
  
Inhibitor
Name:
BDBM50259105
Synonyms:
CHEMBL466680 | N-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl}-2-(tetrahydro-2H-pyran-4-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C22H33N5O3
Mol. Mass.:
415.5291
SMILES:
CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1NC(=O)CC1CCOCC1)[nH]c2=O |r|
Structure:
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