Target
Acid-sensing ion channel 3
Ligand
BDBM50259353
Substrate
n/a
Meas. Tech.
ChEMBL_500746 (CHEMBL970525)
IC50
510±n/a nM
Citation
 Kuduk, SDDi Marco, CNChang, RKDipardo, RMCook, SPCato, MJJovanovska, AUrban, MOLeitl, MSpencer, RHKane, SABilodeau, MTHartman, GDBock, MG Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorg Med Chem Lett 19:2514-8 (2009) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ACCN3 | ASIC3 | ASIC3_HUMAN | Amiloride-sensitive cation channel 3 | SLNAC1 | TNAC1
Type:
PROTEIN
Mol. Mass.:
58910.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_757561
Residue:
531
Sequence:
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
  
Inhibitor
Name:
BDBM50259353
Synonyms:
3-amino-6-chloro-N-(diaminomethylene)-5-(naphthalen-2-ylamino)pyrazine-2-carboxamide | CHEMBL466668
Type:
Small organic molecule
Emp. Form.:
C16H14ClN7O
Mol. Mass.:
355.782
SMILES:
NC(=N)NC(=O)c1nc(Cl)c(Nc2ccc3ccccc3c2)nc1N
Structure:
Search PDB for entries with ligand similarity: