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TargetFructose-1,6-bisphosphatase 1 (FBPase)
LigandBDBM22579
Substrate/Competitorn/a
Meas. Tech.ChEMBL_502048
IC50 12000±n/a nM
Citation Dang, QBrown, BSLiu, YRydzewski, RMRobinson, EDvan Poelje, PDReddy, MRErion, MD Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics. J Med Chem52:2880-98 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphatase 1 (FBPase)
Name:Fructose-1,6-bisphosphatase
Synonyms:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1
Type:Protein
Mol. Mass.:36843.58
Organism:Homo sapiens (Human)
Description:Liver FBPase (P09467)
Residue:338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22579
NameBDBM22579
Synonyms:AICAR | Aminoimidazole-4-carboxamide ribonucleotide | CHEMBL483849 | ZMP | {[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
TypeNucleoside or nucleotide
Emp. Form.C9H15N4O8P
Mol. Mass.338.2112
SMILESNC(=O)c1ncn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c1N
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a