Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50278064
Substrate
n/a
Meas. Tech.
ChEMBL_502048 (CHEMBL981259)
IC50
>100000±n/a nM
Citation
 Dang, Q; Brown, BS; Liu, Y; Rydzewski, RM; Robinson, ED; van Poelje, PD; Reddy, MR; Erion, MD Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics. J Med Chem 52:2880-98 (2009) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50278064
Synonyms:
CHEMBL520176 | [5-(6-Amino-9-phenethyl-9H-purin-8-yl)-furan-2-yl]-phosphonic Acid Monoethyl Ester
Type:
Small organic molecule
Emp. Form.:
C21H24N5O4P
Mol. Mass.:
441.4201
SMILES:
CCOP(=O)(OCC)c1ccc(o1)-c1nc2c(N)ncnc2n1CCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: