Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50259131
Substrate
n/a
Meas. Tech.
ChEMBL_499185 (CHEMBL1012375)
IC50
110000±n/a nM
Citation
 Maryanoff, BE 2009 Edward E Smissman Award. Pharmaceutical"gold" from neurostabilizing agents: topiramate and successor molecules. J Med Chem 52:3431-40 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50259131
Synonyms:
CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-yl)methyl)sulfamide | N-(1-benzothien-3-ylmethyl)sulfamide
Type:
Small organic molecule
Emp. Form.:
C9H10N2O2S2
Mol. Mass.:
242.318
SMILES:
NS(=O)(=O)NCc1csc2ccccc12
Structure:
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