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Target
Elongation of very long chain fatty acids protein 3
Ligand
BDBM50249892
Substrate
n/a
Meas. Tech.
ChEMBL_498150 (CHEMBL1007922)
IC50
194±n/a nM
Citation
 Takahashi, T; Nagase, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem 52:3142-5 (2009) [PubMed]  Article 
Target
Name:
Elongation of very long chain fatty acids protein 3
Synonyms:
Cig30 | ELOV3_MOUSE | Elovl3
Type:
PROTEIN
Mol. Mass.:
32078.38
Organism:
Mus musculus
Description:
ChEMBL_572245
Residue:
271
Sequence:
MDTSMNFSRGLKMDLMQPYDFETFQDLRPFLEEYWVSSFLIVVVYLLLIVVGQTYMRTRKSFSLQRPLILWSFFLAIFSILGTLRMWKFMATVMFTVGLKQTVCFAIYTDDAVVRFWSFLFLLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLLFTSFGYKNKVPSGGWFMTMNFGVHSVMYTYYTMKAAKLKHPNLLPMVITSLQILQMVLGTIFGILNYIWRQEKGCHTTTEHFFWSFMLYGTYFILFAHFFHRAYLRPKGKVASKSQ
  
Inhibitor
Name:
BDBM50249892
Synonyms:
6,6-dimethyl-3-{5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrazol-4-yl}-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione | CHEMBL449121
Type:
Small organic molecule
Emp. Form.:
C28H23F6N3O4
Mol. Mass.:
579.4903
SMILES:
Cc1[nH]n(-c2ccc(OC(F)(F)F)cc2)c(=O)c1C1(C(=O)N(C2=C1C(=O)CC(C)(C)C2)c1ccccc1)C(F)(F)F |c:24|
Structure:
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