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Target
Stearoyl-CoA desaturase
Ligand
BDBM50259217
Substrate
n/a
Meas. Tech.
ChEMBL_499367 (CHEMBL1015819)
IC50
180±n/a nM
Citation
 Koltun, DO; Vasilevich, NI; Parkhill, EQ; Glushkov, AI; Zilbershtein, TM; Mayboroda, EI; Boze, MA; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Chu, N; Hao, J; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett 19:3050-3 (2009) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50259217
Synonyms:
CHEMBL512969 | N-(3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-7-yl)-2-hydroxyacetamide
Type:
Small organic molecule
Emp. Form.:
C17H13Cl2N3O3
Mol. Mass.:
378.209
SMILES:
OCC(=O)Nc1ccc2c(c1)ncn(Cc1ccc(Cl)c(Cl)c1)c2=O
Structure:
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