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Target
Acyl-CoA 6-desaturase
Ligand
BDBM50259175
Substrate
n/a
Meas. Tech.
ChEMBL_499369 (CHEMBL1015821)
IC50
>30000±n/a nM
Citation
 Koltun, DO; Vasilevich, NI; Parkhill, EQ; Glushkov, AI; Zilbershtein, TM; Mayboroda, EI; Boze, MA; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Chu, N; Hao, J; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett 19:3050-3 (2009) [PubMed]  Article 
Target
Name:
Acyl-CoA 6-desaturase
Synonyms:
FADS2_MOUSE | Fads2 | Fadsd2 | Fatty acid desaturase 2
Type:
PROTEIN
Mol. Mass.:
52406.94
Organism:
Mus musculus
Description:
ChEMBL_499369
Residue:
444
Sequence:
MGKGGNQGEGSTERQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVIGHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKTNHLFFFLLLSHIIVMESLAWFILSYFGTGWIPTLVTAFVLATSQAQAGWLQHDYGHLSVYKKSIWNHVVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMISRRDWVDLAWAISYYMRFFYTYIPFYGILGALVFLNFIRFLESHWFVWVTQMNHLVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALIDIVSSLKKSGELWLDAYLHK
  
Inhibitor
Name:
BDBM50259175
Synonyms:
CHEMBL444433 | N-(3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl)-2-hydroxyacetamide
Type:
Small organic molecule
Emp. Form.:
C17H13Cl2N3O3
Mol. Mass.:
378.209
SMILES:
OCC(=O)Nc1ccc2ncn(Cc3ccc(Cl)c(Cl)c3)c(=O)c2c1
Structure:
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