Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50268534
Substrate
n/a
Meas. Tech.
ChEMBL_523817 (CHEMBL1008329)
IC50
0.91±n/a nM
Citation
 Takahashi, T; Haga, Y; Sakamoto, T; Moriya, M; Okamoto, O; Nonoshita, K; Shibata, T; Suga, T; Takahashi, H; Hirohashi, T; Sakuraba, A; Gomori, A; Iwaasa, H; Ohe, T; Ishihara, A; Ishii, Y; Kanatani, A; Fukami, T Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists. Bioorg Med Chem Lett 19:3511-6 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50268534
Synonyms:
CHEMBL521545 | N-(5-(3-chlorophenyl)pyrimidin-2-yl)-3-oxo-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H19ClN4O3
Mol. Mass.:
434.875
SMILES:
Clc1cccc(c1)-c1cnc(NC(=O)N2CCC3(CC2)OC(=O)c2ccccc32)nc1
Structure:
Search PDB for entries with ligand similarity: