Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50280713
Substrate
n/a
Meas. Tech.
ChEMBL_99863 (CHEMBL706933)
IC50
0.400000±n/a nM
Citation
 Labelle, MPrasit, PBelley, MBlouin, MChampion, ECharette, LDeLuca, JGDufresne, CFrenette, RGauthier, JYGrimm, EGrossman, SJGuay, DHerold, EGJones, TRLau, CKLeblanc, YLéger, SLord, AMcAuliffe, M The discovery of a new structural class of potent orally active leukotriene D4 antagonists Bioorg Med Chem Lett 2:1141-1146 (1992)    Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50280713
Synonyms:
CHEMBL15232 | Sodium; 2-{1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(1-methyl-1H-tetrazol-5-yl)-phenyl]-propylsulfanylmethyl}-butyrate
Type:
Small organic molecule
Emp. Form.:
C32H31ClN5O3S
Mol. Mass.:
601.139
SMILES:
CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Structure:
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