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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50280712
Substrate
n/a
Meas. Tech.
ChEMBL_99863 (CHEMBL706933)
IC50
0.360000±n/a nM
Citation
 Labelle, M; Prasit, P; Belley, M; Blouin, M; Champion, E; Charette, L; DeLuca, JG; Dufresne, C; Frenette, R; Gauthier, JY; Grimm, E; Grossman, SJ; Guay, D; Herold, EG; Jones, TR; Lau, CK; Leblanc, Y; Léger, S; Lord, A; McAuliffe, M The discovery of a new structural class of potent orally active leukotriene D4 antagonists Bioorg Med Chem Lett 2:1141-1146 (1992)    Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50280712
Synonyms:
CHEMBL14819 | Sodium; 3-{1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(2H-[1,2,4]triazol-3-yl)-phenyl]-propylsulfanyl}-propionate
Type:
Small organic molecule
Emp. Form.:
C30H26ClN4O3S
Mol. Mass.:
558.071
SMILES:
[O-]C(=O)CCSC(CCc1ccccc1-c1nnc[nH]1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Structure:
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