Reaction Details Report a problem with these data
Target
Inositol monophosphatase 1
Ligand
BDBM50240448
Substrate
n/a
Meas. Tech.
ChEBML_140830
IC50
23000±n/a nM
Citation
 Fletcher, SR; Baker, R; Ladduwahetty, T; Sharpe, A; Teall, M; Atack, JR 4-hydroxyphenoxymethylene bisphosphonic acid derivatives: potent, non-hydrolysable inhibitors of MYO-inositol monophosphatase Bioorg Med Chem Lett 3:141-146 (1993)    Article 
Target
Name:
Inositol monophosphatase 1
Synonyms:
IMPA | IMPA1 | IMPA1_BOVIN | Inositol-1(or 4)-monophosphatase 1
Type:
PROTEIN
Mol. Mass.:
30047.72
Organism:
Bos taurus
Description:
ChEMBL_140831
Residue:
277
Sequence:
MADPWQECMDYAVTLAGQAGEVVREALKNEMNIMVKSSPADLVTATDQKVEKMLITSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHGFPFVAVSIGFVVNKKMEFGIVYSCLEDKMYTGRKGKGAFCNGQKLQVSHQEDITKSLLVTELGSSRTPETVRIILSNIERLLCLPIHGIRGVGTAALNMCLVAAGAADAYYEMGIHCWDVAGAGIIVTEAGGVLLDVTGGPFDLMSRRVIASSNKTLAERIAKEIQIIPLQRDDED
  
Inhibitor
Name:
BDBM50240448
Synonyms:
2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldiphosphonic acid | CHEMBL34249 | [2-(3,4-Dichloro-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C8H10Cl2O7P2
Mol. Mass.:
351.014
SMILES:
OC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O
Structure:
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