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Target
Adenosylhomocysteinase
Ligand
BDBM50280298
Substrate
n/a
Meas. Tech.
ChEBML_196884
Ki
1100±n/a nM
Citation
 Matthews, DP; Edwards, ML; Mehdi, S; Koehl, JR; Wolos, JA; McCarthy, JR (E) and (Z)5′-fluoro olefin carbocyclic nucleosides: effect of olefin geometry on inhibition of s-adenosyl-l-homocysteine hydrolase Bioorg Med Chem Lett 3:165-168 (1993)    Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | Ahcy | SAHH_RAT
Type:
PROTEIN
Mol. Mass.:
47537.52
Organism:
Rattus norvegicus
Description:
ChEMBL_1507790
Residue:
432
Sequence:
MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
  
Inhibitor
Name:
BDBM50280298
Synonyms:
(1R,2S,3R)-3-(6-Amino-purin-9-yl)-5-[1-fluoro-meth-(Z)-ylidene]-cyclopentane-1,2-diol | CHEMBL49204
Type:
Small organic molecule
Emp. Form.:
C11H12FN5O2
Mol. Mass.:
265.2437
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1C\C(=C\F)[C@@H](O)[C@H]1O
Structure:
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