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Target
Endothelin-1 receptor
Ligand
BDBM50281584
Substrate
n/a
Meas. Tech.
ChEMBL_65791 (CHEMBL677972)
IC50
230±n/a nM
Citation
 Spellmeyer, DC; Brown, S; Stauber, GB; Geysen, H; Valerio, R Endothelin receptor ligands. replacement net approach to SAR determination of potent hexapeptides Bioorg Med Chem Lett 3:519-524 (1993)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_MOUSE | Ednra | Endothelin receptor ET-A | Gpcr10
Type:
PROTEIN
Mol. Mass.:
48591.87
Organism:
Mus musculus
Description:
ChEMBL_723169
Residue:
427
Sequence:
MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50281584
Synonyms:
(S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionylamino)-5-amino-pentanoylamino]-N-((1S,2R)-1-{(1S,2R)-1-[(S)-1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid | CHEMBL423941
Type:
Small organic molecule
Emp. Form.:
C43H60N8O10
Mol. Mass.:
848.9841
SMILES:
CC[C@@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Structure:
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