Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50281731
Substrate
n/a
Meas. Tech.
ChEMBL_48271 (CHEMBL663176)
pH
7.4±n/a
IC50
550±n/a nM
Comments
extracted
Citation
 Howbert, JJ; Lobb, KL; Britton, TC; Mason, NR; Bruns, RF Diphenylpyrazolidinone and benzodiazepine cholecystokinin antagonists: A case of convergent evolution in medicinal chemistry Bioorg Med Chem Lett 3:875-880 (1993)    Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49196.59
Organism:
MOUSE
Description:
Cholecystokinin A CCKBR MOUSE::P56481
Residue:
453
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50281731
Synonyms:
(4S,5R)-3-Oxo-4,5-diphenyl-pyrazolidine-1-carbothioic acid (4-chloro-3-trifluoromethyl-phenyl)-amide | CHEMBL169274 | LY-294920
Type:
Small organic molecule
Emp. Form.:
C23H17ClF3N3OS
Mol. Mass.:
475.914
SMILES:
FC(F)(F)c1cc(NC(=S)N2NC(=O)[C@H]([C@@H]2c2ccccc2)c2ccccc2)ccc1Cl
Structure:
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