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Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50281906
Substrate
n/a
Meas. Tech.
ChEBML_140108
Kd
25±n/a nM
Citation
 Malaska, MJ; Fauq, AH; Kozikowski, AP; Aagaard, PJ; McKinney, M Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors Bioorg Med Chem Lett 3:1247-1252 (1993)    Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50281906
Synonyms:
2-[(E)-2-(9,9a-Dihydro-4aH-xanthen-9-yl)-vinyl]-1-methyl-piperidine | CHEMBL25334
Type:
Small organic molecule
Emp. Form.:
C21H25NO
Mol. Mass.:
307.4293
SMILES:
CN1CCCCC1\C=C\C1C2C=CC=CC2Oc2ccccc12 |c:12,14|
Structure:
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