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Target
Type-1 angiotensin II receptor
Ligand
BDBM50003266
Substrate
n/a
Meas. Tech.
ChEMBL_35259 (CHEMBL648565)
IC50
4530±n/a nM
Citation
 Weinstock, J; Hill, DT; Keenan, RM; Franz, RG; Gaitanopoulos, DE; Girard, GR; Eggleston, DS; Aiyar, N; Griffin, E; Ohlstein, E; Brooks, DP; Gellai, M; Frederickson, TA; Weidley, EF; Edwards, RM A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist Bioorg Med Chem Lett 4:23-28 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50003266
Synonyms:
(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid | 3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid | CHEMBL289543
Type:
Small organic molecule
Emp. Form.:
C22H23ClN2O2S
Mol. Mass.:
414.948
SMILES:
CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1Cl
Structure:
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