Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50282993
Substrate
n/a
Meas. Tech.
ChEMBL_192718 (CHEMBL801746)
IC50
0.500000±n/a nM
Citation
 Wester, RT; Chambers, RJ; Green, MD; Murphy, WR Preparation of a novel series of phosphonate norstatine renin inhibitors Bioorg Med Chem Lett 4:2005-2010 (1994)    Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50282993
Synonyms:
(2S,4R)-4-Cyclohexyl-2-hydroxy-3-((R)-3-methylsulfanyl-2-{2-[(morpholine-4-carbonyl)-amino]-3-phenyl-propionylamino}-propionylamino)-butyric acid isopropyl ester | CHEMBL60550
Type:
Small organic molecule
Emp. Form.:
C31H48N4O7S
Mol. Mass.:
620.8
SMILES:
CSC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)N1CCOCC1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)C(=O)OC(C)C
Structure:
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