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Target
Mu-type opioid receptor
Ligand
BDBM50283041
Substrate
n/a
Meas. Tech.
ChEBML_138889
Ki
0.510000±n/a nM
Citation
 Sasaki, Y; Watanabe, Y; Ambo, A; Suzuki, K Synthesis and biological properties of quaternized N-methylation analogs of D-Arg-2-dermorphin tetrapeptide Bioorg Med Chem Lett 4:2049-2054 (1994)    Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50283041
Synonyms:
(R)-2-{2-[2-Amino-4-(2-{(S)-guanidino-1-(S)-2-[(R)-2-amino-3-(4-hydroxy-phenyl)-1-oxo-propylamino]-5-oxo-pentylamino}-3-phenyl-propionylamino)-butyrylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-amino-2-((S)-4-hydroxy-phenyl)-ethyl]-amide | CHEMBL408741
Type:
Small organic molecule
Emp. Form.:
C52H71N15O9
Mol. Mass.:
1050.2152
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O
Structure:
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