Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50283591
Substrate
n/a
Meas. Tech.
ChEMBL_36624 (CHEMBL652864)
IC50
7±n/a nM
Citation
 Thomas, AP; Roberts, DA; Thomason, DA The synthesis and biological activity of tetrahydroquinoline angiotensin II antagonists containing a substituted biphenyltetrazole group Bioorg Med Chem Lett 4:2615-2620 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_CAVPO | AT1 | Angiotensin II type-1 receptor
Type:
PROTEIN
Mol. Mass.:
41004.19
Organism:
Cavia porcellus
Description:
ChEMBL_36783
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
  
Inhibitor
Name:
BDBM50283591
Synonyms:
4-[2-Chloro-2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-2-ethyl-5,6,7,8-tetrahydro-quinoline | CHEMBL314859
Type:
Small organic molecule
Emp. Form.:
C25H24ClN5O
Mol. Mass.:
445.944
SMILES:
CCc1cc(OCc2ccc(c(Cl)c2)-c2ccccc2-c2nnn[nH]2)c2CCCCc2n1
Structure:
Search PDB for entries with ligand similarity: