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Target
Histamine H3 receptor
Ligand
BDBM50283869
Substrate
n/a
Meas. Tech.
ChEMBL_85826 (CHEMBL697664)
Ki
1.58±n/a nM
Citation
 Stark, H; Krause, M; Arrang, JM; Ligneau, X; Schwartz, JC; Schunack, W Unsymmetrically substituted guanidines as potent histamine H3-receptor antagonists Bioorg Med Chem Lett 4:2907-2912 (1994)    Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50283869
Synonyms:
CHEMBL99830 | N-[3-(1H-Imidazol-4-yl)-propyl]-N'-(4-iodo-benzyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C14H18IN5
Mol. Mass.:
383.2307
SMILES:
Ic1ccc(CNC(=N)NCCCc2cnc[nH]2)cc1
Structure:
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