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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50283943
Substrate
n/a
Meas. Tech.
ChEBML_52047
IC50
2.7±n/a nM
Citation
 Labelle, M; Belley, M; Champion, E; Gordon, R; Hoogsteen, K; Jones, TR; Leblanc, Y; Lord, A; McAuliffe, M; McFarlane, C; Masson, P; Metters, KM; Nicoll-Griffith, D; Ouimet, N; Piechuta, H; Rochette, C; Sawyer, N; Xiang, YB; Yergey, J; Ford-Hutchinson, AW The discovery of L-699,392, a novel potent and orally active leukotriene D4 receptor antagonist Bioorg Med Chem Lett 4:463-468 (1994)    Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50283943
Synonyms:
(S)-3-{(S)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanyl}-2-methyl-propionic acid | CHEMBL143874
Type:
Small organic molecule
Emp. Form.:
C33H34ClNO3S
Mol. Mass.:
560.146
SMILES:
C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)C(O)=O
Structure:
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