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Reaction Details
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TargetLTB4R
LigandBDBM50037390
Substrate/Competitorn/a
Meas. Tech.ChEMBL_99648
IC50 14.5±n/a nM
Citation Djuric', SWDocter, SHYu, SSTsai, BSAnglin, CPGaginella, TSKachur, JFKeith, RHMaziasz, TJVillani-Price, DRao, TSWalsh, REWidomski, DLFretland, DJ Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity Bioorg Med Chem Lett4:811-816 (1994)    Article
More Info.:Get all data from this article,  Assay Method
 
LTB4R
Name:LTB4R
Synonyms:Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | LTB4-R 1 | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2Y purinoceptor 7 | P2Y7
Type:Enzyme Catalytic Domain
Mol. Mass.:37582.68
Organism:HUMAN
Description:Leukotriene B4 R1 LTB4R HUMAN::Q15722
Residue:352
Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNL
ALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVA
RPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAF
HLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVV
NLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGF
VAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
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  Blast E-value cutoff:
BDBM50037390
n/a
NameBDBM50037390
Synonyms:3-{(S)-2-(2-Carboxy-ethyl)-7-[3-(2-cyclopropylmethyl-3-methoxy-4-methylcarbamoyl-phenoxy)-propoxy]-chroman-8-yl}-propionic acid | 3-{(S)-7-[3-(2-Cyclopropylmethyl-3-methoxy-4-methylcarbamoyl-phenoxy)-propoxy]-8-propyl-chroman-2-yl}-propionic acid | CHEMBL419948 | SC-53228
TypeSmall organic molecule
Emp. Form.C31H41NO7
Mol. Mass.539.6597
SMILESCCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2CC[C@@H](CCC(O)=O)Oc12
Structure
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