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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50213061
Substrate
n/a
Meas. Tech.
ChEMBL_204581 (CHEMBL814227)
IC50
8.6±n/a nM
Citation
 McDonald, IA; Nyce, PL; Muench, DM; Gates, CA; Blohm, TR; Laughlin, ME; Weintruab, PM Inhibition of steroid 5α-reductase by “inverted”, competitive inhibitors Bioorg Med Chem Lett 4:847-851 (1994)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50213061
Synonyms:
CHEMBL2298601
Type:
Small organic molecule
Emp. Form.:
C24H40N2O2
Mol. Mass.:
388.5866
SMILES:
CCN(CC)C(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C |r|
Structure:
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