Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50284934
Substrate
n/a
Meas. Tech.
ChEBML_159320
IC50
220±n/a nM
Citation
 Ahmad, S; Ashfaq, A; Alam, M; Bisacchi, GS; Chen, P; Cheng, PT; Greytok, JA; Hermsmeier, MA; Lin, PF; Lis, KA; Merchant, Z; Mitt, T; Skoog, M; Spergel, SH; Tino, JA; Vite, GD; Colonno, RJ; Zahler, R; Barrish, JC α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease Bioorg Med Chem Lett 5:1729-1734 (1995)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50284934
Synonyms:
((1S,2R)-1-Benzyl-2-hydroxy-3-{(2R,3S)-2-hydroxy-3-[(3-hydroxy-4,4-dimethyl-tetrahydro-furan-3-carbonyl)-amino]-4-phenyl-butylamino}-propyl)-carbamic acid tert-butyl ester | CHEMBL46067
Type:
Small organic molecule
Emp. Form.:
C32H47N3O7
Mol. Mass.:
585.7315
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)C1(O)COCC1(C)C
Structure:
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