Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50284961
Substrate
n/a
Meas. Tech.
ChEBML_138955
Ki
4100±n/a nM
Citation
 Wu, ES; Mack, RA; Kover, A; Loch, JT; Mullen, G; Murray, RJ; Gordon, JC; Machulskis, AC; McCreedy, SA; Blosser, JC Synthesis and biological activity of enantiomers of a conformationally restricted muscarone analog Bioorg Med Chem Lett 5:1813-1818 (1995)    Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50284961
Synonyms:
(S)-2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one | CHEMBL50898
Type:
Small organic molecule
Emp. Form.:
C10H17NO2
Mol. Mass.:
183.2475
SMILES:
C[C@@H]1OC2(CC1=O)CCN(C)CC2
Structure:
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