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Target
Trypanothione reductase
Ligand
BDBM50096496
Substrate
n/a
Meas. Tech.
ChEBML_211971
Ki
3500±n/a nM
Citation
 O'Sullivan, MC; Zhou, Q Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase Bioorg Med Chem Lett 5:1957-1960 (1995)    Article 
Target
Name:
Trypanothione reductase
Synonyms:
N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR
Type:
Homodimer; oxidoreductase
Mol. Mass.:
53868.26
Organism:
Trypanosoma cruzi
Description:
n/a
Residue:
492
Sequence:
MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEGLEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKPSEASL
  
Inhibitor
Name:
BDBM50096496
Synonyms:
CHEMBL62048 | N,N'-Bis-(3-amino-propyl)-N,N'-bis-(3-phenyl-propyl)-butane-1,4-diamine | N1,N4-bis(3-aminopropyl)-N1,N4-bis(3-phenylpropyl)butane-1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C28H46N4
Mol. Mass.:
438.6916
SMILES:
NCCCN(CCCCN(CCCN)CCCc1ccccc1)CCCc1ccccc1
Structure:
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