Reaction Details Report a problem with these data
Target
Sterol O-acyltransferase 1
Ligand
BDBM50285444
Substrate
n/a
Meas. Tech.
ChEBML_28031
IC50
80±n/a nM
Citation
Wilde, RG; Klaczkiewicz, JD; Billheimer, JT; Wexler, RR; Gillies, PJ Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: heterocyclic bioisosteres for the urea group in DuP 128 Bioorg Med Chem Lett 5:177-180 (1995) Article
More Info.:
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1_MOUSE | Soat1 | Sterol O-acyltransferase 1
Type:
PROTEIN
Mol. Mass.:
63818.83
Organism:
Mus musculus
Description:
ChEMBL_90523
Residue:
540
Sequence:
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLDELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPPASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRDNYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
Inhibitor
Name:
BDBM50285444
Synonyms:
1N,1N-dimethyl-4-{5-(4-dimethylaminophenyl)-2-[5-(2-isopropyl-1H-benzo[d]imidazol-1-yl)pentylsulfanyl]-1H-4-imidazolyl}aniline | CHEMBL51087
Type:
Small organic molecule
Emp. Form.:
C34H42N6S
Mol. Mass.:
566.802
SMILES:
CC(C)c1nc2ccccc2n1CCCCCSc1nc(c([nH]1)-c1ccc(cc1)N(C)C)-c1ccc(cc1)N(C)C