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Target
Sterol O-acyltransferase 1
Ligand
BDBM50285881
Substrate
n/a
Meas. Tech.
ChEBML_28506
IC50
6±n/a nM
Citation
 Obata, R; Sunazuka, T; Tomoda, H; Harigaya, Y; Omura, S Chemical modification and structure-activity relationships of pyripyropenes; potent, bioavailable inhibitor of acyl-CoA: Cholesterol O-acyltransferase (ACAT) Bioorg Med Chem Lett 5:2683-2688 (1995)    Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50285881
Synonyms:
12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(3-pyridyl)-(4aR,6S,6aS,12R,12bS,14aS)-4bH,5H,6H,6aH,11H,12H,12aH,12bH,13H,14H-[1,3]dioxino[4',5':5,6]benzo[f]pyrano[4,3-b]chromen-6-yl 2-aminopentanoat | CHEMBL330686
Type:
Small organic molecule
Emp. Form.:
C37H44N2O8
Mol. Mass.:
644.7539
SMILES:
CCCC(N)C(=O)O[C@H]1CC2[C@](C)(CC[C@@H]3OC(OC[C@@]23C)c2ccccc2)C2[C@@H](O)c3c(O[C@]12C)cc(oc3=O)-c1cccnc1
Structure:
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