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Target
Sterol O-acyltransferase 1
Ligand
BDBM50005944
Substrate
n/a
Meas. Tech.
ChEBML_28484
IC50
110±n/a nM
Citation
 O'Brien, PM; Sliskovic, DR; Bernabei, A; Hurley, T; Anderson, MK; Bousley, RF; Krause, BK; Stanfield, RL Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 13. Design, synthesis and biological evaluation of tetrazole anilides as potent inhibitors of ACAT in vitro and hypocholesterolemic agents in vivo Bioorg Med Chem Lett 5:295-300 (1995)   
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50005944
Synonyms:
2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide | CHEMBL22373 | CI-976
Type:
Small organic molecule
Emp. Form.:
C23H39NO4
Mol. Mass.:
393.5601
SMILES:
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
Structure:
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