Reaction Details Report a problem with these data
Target
Potassium-transporting ATPase alpha chain 1
Ligand
BDBM50286572
Substrate
n/a
Meas. Tech.
ChEBML_29667
IC50
8200±n/a nM
Citation
 Ife, RJ; Leach, CA; Pope, AJ; Theobald, CJ 4-(2-PYRTOYL)-5-phenylthiazoles as novel non-bicyclic reversible inhibitors of the gastric H+/K+-atpase Bioorg Med Chem Lett 5:543-546 (1995)    Article 
Target
Name:
Potassium-transporting ATPase alpha chain 1
Synonyms:
ATP4A | ATP4A_PIG | Gastric H(+)/K(+) ATPase subunit alpha | H+/K+-ATPase | Na/K-ATPase | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump
Type:
Enzyme
Mol. Mass.:
114279.23
Organism:
Sus scrofa (Pig)
Description:
P19156
Residue:
1034
Sequence:
MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY
  
Inhibitor
Name:
BDBM50286572
Synonyms:
2-(2-Propyl-5-o-tolyl-thiazol-4-yl)-pyridine | CHEMBL151183
Type:
Small organic molecule
Emp. Form.:
C18H18N2S
Mol. Mass.:
294.414
SMILES:
CCCc1nc(c(s1)-c1ccccc1C)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: