Reaction Details Report a problem with these data
Target
Potassium-transporting ATPase alpha chain 2
Ligand
BDBM50286740
Substrate
n/a
Meas. Tech.
ChEBML_144115
IC50
400000±n/a nM
Citation
 Haruna, M; Tanaka, M; Sugimoto, T; Kojima, R; Suzuki, Y; Konoshima, T; Kozuka, M; Ito, K Alteration of Na+ permeability in human erythrocytes as studied by 23Na-NMR and inhibition of the kidney Na+,K+-ATPase activities with saponins: Interaction of Gleditsia saponins with human erythrocyte membranes Bioorg Med Chem Lett 5:827-830 (1995)    Article 
Target
Name:
Potassium-transporting ATPase alpha chain 2
Synonyms:
AT12A_HUMAN | ATP12A | ATP1AL1
Type:
PROTEIN
Mol. Mass.:
115509.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_144101
Residue:
1039
Sequence:
MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY
  
Inhibitor
Name:
BDBM50286740
Synonyms:
CHEMBL406262 | Saponin derivative
Type:
Small organic molecule
Emp. Form.:
C112H184O44
Mol. Mass.:
2234.633
SMILES:
CC1OC(COCCCC2OC(CCCOOC(=O)C34CCC(C)(C)CC3C3=CCC5[C@@]6(C)CCC(OC7OC(CCOCCC8OCC(O)C(O)C8OC8OCC(O)C(O)C8O)C(O)C(O)C7O)C(C)(C)C6CC[C@@]5(C)[C@]3(C)C[C@H]4O)C(OCC3OC(C)C(OCCCCCCCCC4OCC(O)C(OC5OCC(O)C(O)C5O)C4O)C(O)C3O)C(O)C2O)C(OC(=O)C(C)=CCC[C@](C)(O)C=C)C(OC(=O)C(\CO)=C\CC[C@](C)(O)C=C)C1O |t:28|
Structure:
Search PDB for entries with ligand similarity: