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Target
Sterol O-acyltransferase 1
Ligand
BDBM50005944
Substrate
n/a
Meas. Tech.
ChEBML_90523
IC50
400±n/a nM
Citation
 Purchase, CF; White, AD; Anderson, MK; Bocan, TM; Bousley, RF; Hamelehle, KL; Homan, R; Krause, BR; Lee, P; Mueller, SB; Speyer, C; Stanfield, RL; Reindel, JF Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines Bioorg Med Chem Lett 6:1753-1758 (1996)    Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1_MOUSE | Soat1 | Sterol O-acyltransferase 1
Type:
PROTEIN
Mol. Mass.:
63818.83
Organism:
Mus musculus
Description:
ChEMBL_90523
Residue:
540
Sequence:
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVGCHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLDELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWAMFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPPASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRDNYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50005944
Synonyms:
2,2-Dimethyl-dodecanoic acid (2,4,6-trimethoxy-phenyl)-amide | CHEMBL22373 | CI-976
Type:
Small organic molecule
Emp. Form.:
C23H39NO4
Mol. Mass.:
393.5601
SMILES:
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
Structure:
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