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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50025356
Substrate
n/a
Meas. Tech.
ChEBML_204900
IC50
40000±n/a nM
Citation
 Guarna, A; Poletti, A; Catrambone, F; Danza, G; Marrucci, A; Serio, M; Celotti, F; Martini, L Synthesis of a chemiluminescent probe useful for the purification of steroid 5α-reductase Bioorg Med Chem Lett 6:1997-2002 (1996)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
PROTEIN
Mol. Mass.:
29788.29
Organism:
Rattus norvegicus
Description:
ChEMBL_1441437
Residue:
259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQELPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLAFLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFVL
  
Inhibitor
Name:
BDBM50025356
Synonyms:
4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid tert-butylamide | CHEMBL710 | Finasteride | N-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H36N2O2
Mol. Mass.:
372.5441
SMILES:
CC(C)(C)NC(=O)C1CCC2C3CCC4NC(=O)C=CC4(C)C3CCC12C |c:18|
Structure:
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