Target
Serine protease 1
Ligand
BDBM50288400
Substrate
n/a
Meas. Tech.
ChEBML_210658
Ki
8.4±n/a nM
Citation
 Galemmo, RAFevig, JMCarini, DJCacciola, JWells, BLHillyer, GLJr., JBRossi, KAStouten, PFAlexander, RSHilmer, RBostrom, LAbelman, MMLee, SLWeber, PCKettner, CAKnabb, RMWexler, RR (N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors Bioorg Med Chem Lett 6:2913-2918 (1996)    Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50288400
Synonyms:
CHEMBL419892 | N-[(5-Amino-1-dihydroxyboranyl-pentylcarbamoyl)-methyl]-N-cyclohexyl-3-phenyl-propionamide
Type:
Small organic molecule
Emp. Form.:
C22H36BN3O4
Mol. Mass.:
417.35
SMILES:
NCCCC[C@H](NC(=O)CN(C1CCCCC1)C(=O)CCc1ccccc1)B(O)O
Structure:
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