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Target
Stromelysin-1
Ligand
BDBM50288704
Substrate
n/a
Meas. Tech.
ChEBML_102083
Ki
20±n/a nM
Citation
 Chapman, KT; Wales, J; Sahoo, SP; Niedzwiecki, LM; Izquierdo-Martin, M; Chang, BC; Harrison, RK; Stein, RL; Hagmann, WK Inhibition of matrix metalloproteinases by P1 substituted N-carboxyalkyl dipeptides Bioorg Med Chem Lett 6:329-332 (1996)    Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50288704
Synonyms:
(R)-7-Benzoylamino-2-[(S)-1-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-heptanoic acid | CHEMBL326795
Type:
Small organic molecule
Emp. Form.:
C36H46N4O5
Mol. Mass.:
614.7742
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)N[C@H](CCCCCNC(=O)c1ccccc1)C(O)=O)C(=O)Nc1ccccc1
Structure:
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