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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50072190
Substrate
n/a
Meas. Tech.
ChEBML_202913
Ki
20000±n/a nM
Citation
 Abell, AD; Brandt, M; Levy, MA; Holt, DA A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme Bioorg Med Chem Lett 6:481-484 (1996)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50072190
Synonyms:
(R)-8-Chloro-4,10b-dimethyl-1,5,6,10b-tetrahydro-2H-phenanthridin-3-one | CHEMBL97266
Type:
Small organic molecule
Emp. Form.:
C15H16ClNO
Mol. Mass.:
261.747
SMILES:
CC1C(=O)CC[C@@]2(C)C1=NCc1cc(Cl)ccc21 |t:9|
Structure:
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