Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50289059
Substrate
n/a
Meas. Tech.
ChEBML_160737
pH
4.7±n/a
IC50
91±n/a nM
Comments
extracted
Citation
 Hamilton, HW; Tait, BD; Gajda, C; Hagen, SE; Ferguson, D; Lunney, EA; Pavlovsky, A; Tummino, PJ 6-Phenyl-6-alkylamido-5,6-dihydro-2H-pyran-2-ones: novel HIV protease inhibitors Bioorg Med Chem Lett 6:719-724 (1996)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50289059
Synonyms:
5-[4-Hydroxy-5-(2-isopropyl-phenylsulfanyl)-6-oxo-2-phenyl-3,6-dihydro-2H-pyran-2-yl]-pentanoic acid phenylamide | CHEMBL423628
Type:
Small organic molecule
Emp. Form.:
C31H33NO4S
Mol. Mass.:
515.663
SMILES:
CC(C)c1ccccc1SC1C(=O)CC(CCCCC(=O)Nc2ccccc2)(OC1=O)c1ccccc1
Structure:
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